The creation of life from the disintegration of an Engineer in the film's opening scene was created by WETA Digital. The scene was difficult to produce because it had to convey the story of the Engineer's DNA breaking apart, reforming and recombining into Earth DNA in a limited span of time. The team focused on making the DNA stages distinct to convey its changing nature. Scott requested the studio to focus on the destruction occurring within the Engineer. A light color scheme was used for the Engineer's DNA and decayed fish spines were used as an image reference, while the infected DNA had a melted appearance. To find methods of depicting the DNA destruction, the team carved vein-like structures from silicone and pumped black ink and oils into them while filming the changes occurring over an extended period of time.
Following clues to the origin of mankind a team journey across the universe and find a structure on a distant planet containing a monolithic statue of a humanoid head and stone cylinders of alien blood but they soon find they are not alone.