One of the most disturbing and inspiring movies is Mike Figgis' Leaving Las Vegas, where Nicolas Cage plays Benjamin, an alcoholic who's lost his family and his job, then moves to Las Vegas to quite deliberately drink himself to death over the course of four weeks' time.
Leaving Las Vegas is about a man who moves to Vegas and drinks himself to death. It's not a comedy, and it's very depressing.
A brilliant movie about alcoholism must by definition be unsatisfying, but this one is a breakthrough. For all its sincerity and virtue, Leaving Las Vegas is a movie that empties you out, and doesn't give much back.