Moss appeared on Oasis singles 'Don't Go Away' and 'Fade Away', and on the Be Here Now album, playing tambourine, Johnny Depp playing a guitar. She has appeared in music videos such as 'Kowalski' by Primal Scream, 'I Just Don't Know What to Do with Myself' by the White Stripes, 'Something About the Way You Look Tonight' by Elton John, 'Sex with Strangers' by Marianne Faithfull, 'Love Don't Bother Me' by Stage Dolls, 'Delia's Gone' and 'God's Gonna Cut You Down' by Johnny Cash, and 'Queenie Eye' by Paul McCartney.
She has also provided vocals for songs by Primal Scream (the 2003 version of Some Velvet Morning), Babyshambles (La Belle et la Bête) and The Lemonheads (You're a Dirty Robot). Prior to breaking up with Pete Doherty, Moss co-wrote four songs on Babyshambles' second album Shotter's Nation—"You Talk", "French Dog Blues", "Baddie's Boogie", and "Deft Left Hand". In 1999, Moss played a non-musical role in the British screen comedy Blackadder: Back & Forth, appearing both as Maid Marian and as a fictional Queen of England "who looks good naked". Director and writer Richard Curtis said in the making of video, that they wanted "the best looking woman in England" to play the role.
Moss put her name to four perfume lines. Her first one, the original, is named "Kate Moss". Other perfumes include Vintage Muse, Lila Belle and Love Blossoms.
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According to Forbes, her 2004–2005 earnings were $5 million and her 2005–2006 earnings were $8 million.
In 2007, with estimated earnings of $9 million, she was the second highest paid model in the world, behind Gisele Bündchen.
She made her first appearance in the British women's Sunday Times Rich List in 2007, where she was estimated to be worth £45 million. She ranked as the 99th richest woman in Britain.
In the 2009 Rich List, she was ranked as the 1,348th richest person in the UK, with a net worth of £40 million.
In July 2007, when she had earned an estimated total of $9 million in the preceding 12 months, Forbes magazine named her second on the list of the World's 15 top-earning models list.