After the end of her marriage to Rourke, Otis gradually resumed modeling. In 2000, she became one of the oldest models to appear in the Sports Illustrated swimsuit issue, although in 1989 Christie Brinkley who was 34 and Cheryl Tiegs at 42 were featured prominently in the 25th Anniversary edition of Sports Illustrated. Shortly thereafter, she began recovering from anorexia nervosa.
Otis was married to Wild Orchid co-star Mickey Rourke from June 1992 to December 1998.
In 1994 Rourke was arrested for spousal abuse. The charges were later dropped. The couple reconciled and also starred together in Exit in Red, but their marriage ended in December 1998. During their time together according to Otis' autobiography Rourke was abusive, holding a gun to her head on one occasion. Otis was also accidentally shot by one of Rourke's guns. She married Matthew Sutton in 2005 and has two children.
Otis and writer Hugo Schwyzer co-authored Beauty, Disrupted: A Memoir, an autobiography that detailed Otis' marriage to Rourke