In 2011, Gugino appeared as Madame Vera Gorsky in Zack Snyder's action-fantasy film Sucker Punch alongside Abbie Cornish and Emily Browning. Gugino sang a duet with co-star Oscar Isaac, which appeared in the end credits and in the film's soundtrack. She also guest starred on the fourth season of Californication as Abby Rhodes, Hank Moody's attorney and love interest.

In the mid-2012, Gugino had a lead role as Susan Berg, a Washington D.C. investigative reporter, on the USA Network's miniseries Political Animals.

gugino carla
1989Troop Beverly HillsChica Barnfell
1990Welcome Home, Roxy CarmichaelYoung Roxy Carmichael
1993This Boy's LifeNorma Hansen
1993Red HotValentina
1993Son in LawRebecca ' Becca' Warner
1995Miami RhapsodyLeslie Marcus
1996JadedMegan 'Meg' Harris
1996Homeward Bound II: Lost in San FranciscoDelilahVoice role
1996The War at HomeMelissa
1996Wedding Bell BluesViolet
1998Snake EyesJulia Costello
1998Judas KissCoco Chavez
1999A Season for MiraclesEmilie ThompsonTV movie
2001Spy KidsIngrid Cortez
2001The Center of the WorldJerri
2001The Jimmy ShowAnnie
2001The OneT. K. Law/Massie Walsh
2002Spy Kids 2: The Island of Lost DreamsIngrid Cortez
2003The Singing DetectiveBetty Dark/Hooker
2003Spy Kids 3-D: Game OverIngrid Cortez
2005The Life CoachCarla
2005Sin CityLucille
2006Even MoneyVeronica
2006Night at the MuseumRebecca Hutman
2007The LookoutJanet
2007Rise: Blood HunterEve
2007American GangsterLaurie Roberts
2008Righteous KillDet. Karen Corelli
2009The UnbornJanet Beldon
2009SparksRobinShort film
2009WatchmenSally Jupiter/Silk Spectre
2009Race to Witch MountainDr. Alex Friedman
2009Women in TroubleElektra Luxx
2009Under the HoodSally Jupiter/Silk SpectreDirect-to-video release
2010The Mighty MacsCathy Rush
2010Elektra LuxxElektra Luxx
2010Every DayRobin
2011I Melt With YouLaura
2011Girl Walks into a BarFrancine Driver
2011Sucker PunchDr. Vera Gorski
2011Mr. Popper's PenguinsAmanda Popper
2011New Year's EveDr. Morriset
2012Hotel NoirHanna Click
2013By Virtue FallActress
2013Man of SteelKelor (uncredited)[14]Voice role
2014Almost HeroesKatherine
2015San AndreasEmma
2016The Space Between UsFilming

Carla Gugino