His style, reliant on paints and airbrushing as well as inks, was strongly influenced by Frank Frazetta and Bill Sienkiewicz, and took inspiration from rock album covers and graffiti as well as traditional comics art. He spawned many imitators, and for much of the nineties these imitations of his style became the dominant form of artwork in 2000 AD.
While still a student Bisley did a painting of a robot holding a baby that he sent to the offices of 2000 AD. The image was seen by Pat Mills and inspired him to relaunch the ABC Warriors strip with Bisley as artist in 1987. Following this he took over drawing of SlÃ¡ine. Bisley also painted the much anticipated cross-over of Judge Dredd and Batman, Judgement on Gotham.
Simon Bisley is currently an occasional contributor to Heavy Metal.